#deg diethylene glycol

[ivandiaz26623]

Top Di Ethylene Glycol (DEG) Manufacturer | Leading Supplier And Manufacturer of Chemical and Petrochemical Products | Chemical Iran

Looking for a reliable diethylene glycol (DEG) manufacturer? Choose Chemical Iran, your trusted partner for top-quality chemical and petrochemical products. With years of experience, we ensure dependable service, competitive pricing, and timely delivery. Visit our website now to learn more about our wide range of offerings and how we can support your business with premium-grade DEG and other chemicals!

[petrochemical07]

Understanding Key Industrial Chemicals and Their Suppliers

In today’s industrial landscape, specific chemicals play a vital role across various sectors, from manufacturing to agriculture. This article delves into essential Barite suppliers compounds like monoethylene glycol (MEG), diethylene glycol (DEG), bentonite powder, barite powder, caustic soda, and sodium bicarbonate. We’ll explore their uses, suppliers, pricing trends, and why they matter in various industries.

What is Monoethylene Glycol?

Monoethylene glycol (MEG) is a colorless, odorless liquid. It serves multiple purposes, including:

Antifreeze in cooling systems: MEG prevents the freezing of engine coolants.

Production of polyester fibers: MEG is crucial in manufacturing PET (polyethylene terephthalate).

As a solvent in various applications: Industries use it in paints, inks, and coatings.

Pricing and Suppliers

The price of MEG fluctuates based on demand, production costs, and market trends. Recently, the average price of MEG has been around $900 to $1,100 per ton. Key suppliers and manufacturers include:

BASF

SABIC

LyondellBasell

These companies dominate the market due to their extensive production capabilities and global reach.

Diethylene Glycol: An Overview

Diethylene glycol (DEG) is another essential chemical derived from ethylene glycol. It has several industrial applications:

Used as a solvent: DEG is effective in formulations for paints and varnishes.

Manufacturing plasticizers: These additives enhance the flexibility of plastics.

In the production of resins: DEG plays a crucial role in making polyester and epoxy resins.

Market Dynamics and Prices

Currently, the price for DEG is in the range of $1,000 to $1,200 per ton. Major suppliers include:

Reliance Industries

Eastman Chemical Company

Shell Chemicals

These suppliers help maintain a steady flow of DEG into the market, meeting the demands of various sectors.

Bentonite Powder: Importance and Applications

Bentonite powder is a versatile clay material widely used in various industries, including:

Construction: It acts as a sealant for landfills and ponds.

Oil and gas: Bentonite serves as a drilling mud, aiding in the extraction of oil and natural gas.

Foundry: It is crucial in molding sand for metal casting.

Pricing and Suppliers

The price of bentonite powder typically ranges from $75 to $150 per ton, depending on quality and purity. Notable suppliers include:

Black Hills Bentonite

American Colloid Company

Ashapura Group

These manufacturers ensure a consistent supply of bentonite to meet industry demands.

Barite Powder: Essential for Drilling

Barite powder is crucial in the oil and gas industry, primarily as a weighting agent in drilling fluids. Its high density helps control pressure while drilling, preventing blowouts.

Market Pricing and Suppliers

Barite prices hover around $150 to $200 per ton. Key suppliers in the market include:

Schlumberger

Halliburton

BariteWorld

These companies provide reliable sources of barite, supporting the energy sector's needs.

Caustic Soda: A Fundamental Chemical

Caustic soda (sodium hydroxide) is a strong alkaline compound essential for various processes, including:

Manufacturing soap and detergents: It’s a key ingredient in saponification.

Chemical manufacturing: Used to produce various chemicals, including chlorine and plastics.

Pulp and paper: Caustic soda is used in the pulping process to separate lignin from cellulose.

Supplier Landscape and Pricing

The price of caustic soda generally ranges from $500 to $800 per ton. Major suppliers include:

OxyChem

Dow Chemical

Westlake Chemical

These manufacturers maintain significant production capacities, ensuring steady availability in the market.

Sodium Bicarbonate: Versatile and Essential

Sodium bicarbonate, commonly known as baking soda, has various applications:

Food industry: It serves as a leavening agent in baking.

Pharmaceuticals: Used in antacids and as a pH buffer.

Cleaning: Effective in various cleaning products due to its mild abrasive properties.

Pricing and Supplier Insights

The price of sodium bicarbonate typically ranges from $300 to $500 per ton. Key suppliers include:

Solvay

Church & Dwight

Tosoh

These suppliers play a critical role in ensuring the availability of sodium bicarbonate across sectors.

Soda Ash: An Industry Staple

Soda ash (sodium carbonate) is a fundamental chemical used in glass manufacturing, detergents, and other applications.

Supplier Landscape and Pricing

The price of soda ash generally ranges from $300 to $600 per ton. Leading suppliers include:

OCI Chemical Corporation

Ciner Resources

Tronox

These companies provide essential supplies to various industries, maintaining a robust market presence.

Conclusion

Understanding the significance Mineral and market dynamics of these chemicals is vital for industries that rely on them. From MEG and DEG to bentonite and barite powders, each chemical serves critical roles across sectors. Reliable suppliers and competitive pricing ensure that manufacturers can maintain their production processes efficiently.

This overview helps readers grasp the importance of these chemicals, their suppliers, and current market trends. By staying informed about these aspects, businesses can make better decisions regarding sourcing and production strategies.

[chowdhry01]

Exploring the Impact of Diethylene Glycol Manufacturers in India

Diethylene glycol, a versatile compound, plays a significant role in various industrial applications, including antifreeze, plasticizers, and solvents. Understanding the contributions of diethylene glycol manufacturers in India is essential for businesses seeking quality raw materials for their production processes.

What is Diethylene Glycol?

Diethylene glycol (DEG) is a colorless, odorless liquid with hygroscopic properties. It is commonly used in the production of antifreeze and coolants, as well as in the manufacturing of plasticizers and resins. The demand for high-quality DEG is increasing across various sectors, making the role of manufacturers critical.

The Importance of Diethylene Glycol Manufacturers in India

Quality Production:

The best diethylene glycol manufacturers in India adhere to stringent quality control measures to ensure that the DEG produced meets international standards. This is crucial for industries relying on the purity and consistency of raw materials.

Diverse Applications:

DEG is utilized in various industries, including automotive, cosmetics, and pharmaceuticals. Reliable diethylene glycol manufacturers in India can cater to the diverse needs of these sectors by providing specialized products.

Economic Impact:

The growth of diethylene glycol manufacturers in India contributes to the country’s economy by creating jobs and fostering industrial growth. These manufacturers play a pivotal role in the global supply chain for DEG.

Sustainability Initiatives:

Many manufacturers are focusing on sustainable practices, including recycling and reducing waste. Partnering with eco-conscious diethylene glycol manufacturers in India can help businesses meet their sustainability targets.

Conclusion

The contributions of diethylene glycol manufacturers in India are invaluable to various industries. By choosing reputable suppliers, businesses can ensure they are receiving high-quality materials that enhance their production processes and contribute to overall efficiency.

[chemanalystdata]

Diethylene Glycol Prices | Pricing | Trend | News | Database | Chart | Forecast

Diethylene Glycol (DEG) is an essential chemical compound widely used in various industrial applications, including antifreeze, plasticizers, and the production of resins. The prices of diethylene glycol can fluctuate significantly due to several factors such as raw material availability, manufacturing costs, market demand, and global economic conditions. Understanding the dynamics of DEG pricing is crucial for manufacturers, suppliers, and consumers in industries that depend on this compound. Over the years, the price of DEG has been influenced by the interplay of these factors, creating a complex market environment.

One of the most critical factors affecting diethylene glycol prices is the availability and cost of its raw materials, primarily ethylene. Ethylene is a key feedstock in the production of diethylene glycol, and any disruption in its supply or fluctuations in its price can have a direct impact on DEG pricing. The global ethylene market is subject to frequent volatility due to factors such as crude oil prices, natural gas availability, and geopolitical tensions. Since ethylene is derived from petrochemical sources, the price of crude oil plays a significant role in determining the cost of producing DEG. When crude oil prices rise, the cost of ethylene production increases, which in turn raises the price of DEG. Conversely, a drop in crude oil prices can lead to a reduction in the cost of ethylene and, consequently, a decrease in DEG prices.

In addition to raw material costs, the supply and demand balance in the market plays a vital role in determining the price of diethylene glycol. The demand for DEG is driven by its use in various industries, including textiles, automotive, and construction. When these industries experience growth, the demand for DEG increases, putting upward pressure on prices. Conversely, when these industries face downturns, the demand for DEG may decrease, leading to lower prices. Seasonal variations can also affect demand. For instance, DEG is commonly used in antifreeze formulations, so demand tends to increase during colder months, leading to potential price spikes.

Get Real Time Prices for Diethylene Glycol (DEG): https://www.chemanalyst.com/Pricing-data/diethylene-glycol-66

Another significant factor influencing diethylene glycol prices is the capacity and operational efficiency of production facilities. Any disruption in production, such as plant maintenance, technical issues, or natural disasters, can reduce the supply of DEG, leading to price increases. Moreover, expansions or new plant openings can increase supply, which may result in downward pressure on prices if demand remains constant. The geographical distribution of production facilities also plays a role. Regions with a high concentration of DEG production, such as Asia, tend to have more stable prices due to their large output capacity. In contrast, regions that rely on imports may experience higher price volatility due to shipping costs and supply chain disruptions.

International trade policies and tariffs are additional factors that can influence diethylene glycol prices. Trade restrictions, tariffs, or sanctions imposed on key producing countries can disrupt the global supply chain, leading to price increases in regions that rely heavily on imports. Conversely, free trade agreements or reductions in tariffs can promote a more competitive market, leading to lower prices for consumers. In recent years, trade tensions between major economies have created uncertainty in the global market, contributing to fluctuations in DEG prices.

The environmental regulations governing the production and use of diethylene glycol also impact its market price. As concerns about environmental sustainability grow, stricter regulations on chemical manufacturing processes have been introduced in various countries. Compliance with these regulations often requires companies to invest in cleaner technologies and more efficient production processes, which can increase production costs. These costs are typically passed on to consumers in the form of higher prices. Furthermore, regulations that restrict the use of DEG in certain applications, such as in consumer products, can reduce demand, potentially leading to lower prices.

The role of technological advancements in diethylene glycol production cannot be overlooked. Innovations in production processes, such as the development of more efficient catalytic systems or energy-saving technologies, can reduce manufacturing costs and, consequently, the price of DEG. Companies that adopt these technologies may gain a competitive advantage by offering lower prices, thus influencing overall market trends. However, the initial investment in new technologies can be high, which may temporarily result in higher prices as companies seek to recoup their costs.

Global economic conditions also have a significant impact on diethylene glycol prices. During periods of economic growth, industrial activity tends to increase, boosting demand for DEG and leading to higher prices. Conversely, during economic downturns, industrial output may decline, reducing demand and putting downward pressure on prices. The COVID-19 pandemic, for example, led to a sharp reduction in industrial activity in many sectors, resulting in lower demand for DEG and a subsequent decline in prices. As economies recover, demand for DEG is expected to increase, which could lead to price hikes.

In recent years, the DEG market has been influenced by shifts in consumer preferences and the growing emphasis on sustainability. The increasing demand for eco-friendly products has led to a rise in the use of bio-based chemicals as alternatives to petrochemical-based products like DEG. As a result, the DEG market has faced some competition from bio-based glycols, which may exert downward pressure on prices. However, the production of bio-based glycols is still in its early stages and is often more expensive than conventional DEG production, meaning that bio-based alternatives have not yet significantly affected DEG prices on a global scale.

In conclusion, diethylene glycol prices are influenced by a multitude of factors, including raw material costs, supply and demand dynamics, production capacity, international trade policies, environmental regulations, technological advancements, and global economic conditions. As the DEG market continues to evolve, stakeholders must closely monitor these variables to make informed decisions. With the ongoing developments in sustainability and technology, the DEG market may witness further shifts in pricing trends in the future. Despite the challenges posed by market volatility, the demand for diethylene glycol is expected to remain strong across various industries, ensuring its continued importance in the global chemical market.

Get Real Time Prices for Diethylene Glycol (DEG): https://www.chemanalyst.com/Pricing-data/diethylene-glycol-66

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[namansharma0950]

ジエチレングリコール (Diethylene Glycol) の価格動向: 詳細なチャート、市場分析、将来の見通し

ジエチレングリコール (Diethylene Glycol) の価格はさまざまな要因の影響を受けるため、業界関係者は市場動向を常に把握しておくことが不可欠です。DEG は、不凍液、ブレーキ液��製造、樹脂や可塑剤の製造における溶剤など、さまざまな用途で使用される多用途の化学物質です。DEG の価格動向は、主に原材料のコスト、生産能力、業界全体の需要、および世界経済状況によって左右されます。

DEG 価格の主な決定要因の 1 つは、その生産に使用される主要な原材料であるエチレンオキシドのコストです。エチレンオキシドの価格は、原油と天然ガスから得られるエチレンの価格と密接に関連しています。したがって、原油価格の変動は、エチレンオキシド、ひいては DEG の生産コストに大きな影響を与えます。原油価格が上昇すると、エチレンとエチレンオキシドのコストが上昇し、DEG 価格が上昇します。逆に、原油価格が下落すると、DEG の生産コストが下がり、市場価格が下がる可能性があります。

さまざまな業界からの需要も、DEG の価格に影響を与える上で重要な役割を果たしています。不凍液および冷却剤業界は、特にこれらの製品の需要が高い厳しい冬の気候の地域で、DEG の最大の消費者の 1 つです。さらに、DEG は樹脂や可塑剤の製造における溶剤として使用されるため、その価格はプラスチックおよび建設業界の業績に左右されます。したがって、経済成長、産業生産���、建設活動レベルは、DEG の需要とその市場価格に直接影響を与える可能性があります。

生産能力と供給動向も DEG の価格に影響します。工場のメンテナンス、予期しない停止、サプライ チェーンの問題など、生産に混乱が生じると、市場での DEG の入手性が制限され、価格が上昇する可能性があります。一方、生産能力の拡大や既存工場の生産量の増加は供給を増加させ、需要が追いつかなければ価格が下がる可能性があります。

リアルタイムでジエチレングリコール (Diethylene Glycol)価格: https://www.analystjapan.com/Pricing-data/diethylene-glycol-150

世界貿易と地政学的要因も DEG の価格変動にさらに影響します。主要な生産国と消費国間の貿易政策、関税、輸出入規制は、さまざまな地域での DEG の入手性とコストに影響を与える可能性があります。さらに、為替レートは輸入原材料や完成品の価格に影響を及ぼし、現地市場での価格調整につながる可能性があります。

要約すると、ジエチレングリコールの価格は、原材料費、産業需要、生産能力、および世界経済状況の相互作用によって形成されます。DEG に依存する企業にとって、これらの要因を理解し、市場動向を監視することは、情報に基づいた調達と価格決定を行うために不可欠です。

ANALYST JAPAN

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[elysianpens]

REVIEW ON PHARMACEUTICAL REGULATORY AFFAIRS

Ilamathi.A.S, M.Sc., Microbiology. Nikkila devi.R, M.Sc., Microbiology.

ABSTRACT:

Regulatory affairs in the pharmaceutical industry play an important role in ensuring the safety, efficacy, and quality of medicinal products worldwide. The pharmaceutical drug regulatory affairs profession was developed from the desire all over the world to protect public health by providing good quality medicine including safety and efficacy in the area of not only pharmacy but also in the area of veterinary medicine, medical devices, insecticides, pesticides, agrochemical, cosmetic and complementary medicine. Regulatory affairs acts as an interface between the pharmaceutical company and the regulatory agencies. The key role of regulatory affairs professions includes maintaining Compliance, Product approval, Risk management, Market access, Quality assurance. It works under proper organizational structure and various regulatory bodies around the world. Regulatory affairs professional also involves in clinical trail and R&D to develop innovative products that take advantage of new technological and regulatory developments to accelerate time to market. They can face regulatory non-compliance issues, but drug developers can also look to tech-enabled solutions to improve regulatory compliance. Regulatory affairs should explore whether the different innovation in pharma can decrease the risk of compliance issues.

Keywords: Regulatory affairs, Safety, Efficacy, Regulatory agencies, Accuracy, Clinical trail, R&D, Non-compliance.

INTRODUCTION:

Regulatory affairs covers a broad range of specific skills and occupations. Under the best of circumstances, it is composed of a group of people who act as a liaison between the potentially conflicting worlds of government, industry, and consumers to help make sure that marketed products are safe and effective when used as advertised. People who work in regulatory affairs negotiate the interaction between the regulators (the government), the regulated (industry), and the market (consumers) to get good products to the market and to keep them there while preventing bad products from being sold.1

Regulatory affairs is a profession developed from the desire of governments to protect public health by controlling the safety and efficacy of products in areas including pharmaceuticals, veterinary medicines, medical devices, pesticides, agrochemicals, cosmetics and complementary medicines, and by the companies responsible for the discovery, testing, manufacture and marketing of these products wanting to ensure that they supply products that are safe and make a worthwhile contribution to public health and welfare. A new class of professionals emerged to handle these regulatory matters for companies.1

Regulatory affairs in the pharma industry:

Pharma regulatory affairs professionals are key players in drug development, maintaining a vital communications link between the pharmaceutical company and regulatory agencies like the FDA in the United States, TGA in Australia, MHRA in the United Kingdom, and MCC in South Africa, to name a few.

Regulatory affairs departments interact with worldwide, federal, state, and local regulatory agencies to assure that the following activities involving pharmaceutical and medical products are conducted in compliance with all applicable rules:

• Licensing

• Registration

• Development

• Manufacturing

• Marketing

• Labeling

HISTORICAL OVERVIEW OF REGULATORY AFFAIRS:

Elixir Sulfanilamide incident:

The Elixir Sulfanilamide disaster of 1937 was one of the most consequential mass poisonings of the 20th century. Sulfanilamide, an antibacterial drug, was being used safely in the treatment of streptococcal infections. A new elixir formulation with raspberry flavour was prepared using 70% diethylene glycol (DEG) as there was a need for the drug in its liquid form. DEG can be fatal, and unknowingly the company distributed the product across the United States. The formulation resulted in the death of 105 patients who consumed the elixir.

This incident led to the enactment of the Federal Food, Drug, and Cosmetic Act (FD&C Act) in the United States in 1938.

Acts and Rules in India during 20th century:

1. 1900-1960:

• The Poisons Act, 1919 is to check and hold the control on cheap drugs available in market. This Act helps in the administered possession of substance or sale of substances as specified as poison. It also stated the sale and protected custody of the poisons, packaging and labeling of poisons, maximum quantity to be sold and inspection as well as examination of the poison sold by vendor during the year.

• The Dangerous Drugs Act, 1930 which includes the regulation of cultivation, manufacturing possession and trade of opium. In 1985, Dangerous Drugs Act 1930 and Opium Act 1878 was revoked by passing of the Narcotics and Psychotropic Substances Act.

• Drugs and Cosmetics Act, 1940: This act regulates the manufacturing distribution , import and sale of allopathic, homeopathic, unani and siddha drugs.

• Drugs and Cosmetics Rules, 1945: This act regulates manufacture of Ayurvedic drugs for sale only, and not for consumption and use or possession.

• Pharmacy Act, 1948: This law was amended in 1985 and it generally controls and regulates the profession of pharmacy in India.

• Drugs and Magic Remedies (Objectionable Advertisements) Rule. 1955: The regulates the advertisement of drugs in India.

• Drugs Prices Control Order, 1955 (DPCO) (under the essential commodities Act) : DPCO was further amended in 1995. As per this rule, government has a jurisdiction to review and fix maximum sale price for bulk drugs as well as formulation.

2. 1960-1970:

The Indian Pharmaceutical industry was not mature enough and major market share was dominated by MNC and very few Indian manufacturers were in competition. Focus on pure research and development was very little because of deficiency of patent protection. The low availability and high drug price is because majority shares depend upon the high drug import.

3. 1970-1980:

Government took control for the medicines regulation and issued few act and rules.

• Indian Patent Act 1970 (which came in force on 20 Apr 1972 and replaced Indian Patents and Designs Act of 1911): It serves as the basis for patent protection in India. Under this Act product patent was not allowed but the process and method of manufacturing of Drug substance was allowed to get the parent.

• Drug price capped: Drug Prices Control Order (DPCC) was introduced to con the high price against consumers.

4. 1980-1990:

The Indian industry has started investing in process development of APL and created production infrastructure for the same.

5. 1990-2000:

A rapid expansion in domestic market has observed in pharmaceutical industry. The companies have started entering into Research and Development.

6. 2000-2010:

This period is considered to be the Innovation and Research era . During these years, innovative research activity, patenting of the drugs formula, process, indication as well as merger of companies was started.2

Patent Amendment Act 2005:

Indian Government brought out the patents (Amendment) Ordinance, 2004 to address the issues relating to the patent in the country which was later replaced by the Indian Patent (Amendment) Act, 2005. The new Act brought some crucial changes on the legal regime of patent protection so as to address patent issue in technology, chemical and pharmaceutical sector.2

Compulsory Licenses:

Compulsory licenses can be granted for manufacture and export of the drug products “to any country having insufficient or no manufacturing capacity, for the said product, to address public health problems.”

• Drugs and Cosmetics (First Amendment) Rules, 2011: It mandates registration of Clinical Research Organization (CRO) for conducting Clinical Trials (CT).

• Clinical Trial Registry - India (CTRI): It has been set up by the ICMR’S (Indian Council of Medical Research) National Institute of Medical Statistics (NIMS).

• Pharmacovigilance Program of India (PvPI): The Central Drug Standard Control Organization (CDSCO) has launched pharmacovigilance to assure drugs safety to Indian patients.2

WHY IS REGULATORY AFFAIRS IMPORTANT IN PHARMA INDUSTRY?

1. Compliance:

The pharmaceutical industry is highly regulated to ensure the safety, efficacy, and quality of drugs. Regulatory affairs professionals ensure that companies comply with local and international regulations, standards, and guidelines set by regulatory authorities such as the FDA (Food and Drug Administration) in the United States, the EMA (European Medicines Agency) in Europe, and others globally.

2. Product Approval:

Before a pharmaceutical product can be marketed and sold, it must undergo rigorous regulatory review and approval processes. Regulatory affairs professionals are responsible for preparing and submitting applications for regulatory approval, including compiling comprehensive data on the drug's safety, efficacy, manufacturing processes, and quality controls.

3. Risk Management:

Regulatory affairs professionals help identify and mitigate risks associated with pharmaceutical products throughout their lifecycle. This includes assessing potential safety issues, managing adverse events reporting, and ensuring compliance with post-marketing surveillance requirements.

4. Market Access:

In many countries, access to pharmaceutical products is dependent on regulatory approval. Regulatory affairs professionals work to navigate the complexities of different regulatory systems to ensure timely market access for their company's products, which is critical for commercial success.

5. Quality Assurance:

Regulatory affairs professionals collaborate closely with quality assurance teams to establish and maintain high standards for manufacturing processes, packaging, labeling, and distribution of pharmaceutical products. They ensure that products meet regulatory requirements for safety, efficacy, and quality throughout their lifecycle.

6. Legal and Ethical Compliance:

Regulatory affairs professionals must stay abreast of evolving regulatory requirements, industry trends, and ethical standards. They help companies navigate legal and ethical challenges related to drug development, marketing, and distribution, ensuring compliance with laws and regulations governing pharmaceutical activities.

Overall, regulatory affairs serve as a bridge between pharmaceutical companies and regulatory authorities, ensuring that drugs are developed, manufactured, and marketed in compliance with applicable regulations to protect public health and safety.

THE ROLE OF THE REGULATORY PROFESSIONALS:

Regulatory professionals are responsible for:

1. Keeping track of the ever-changing legislation in all the regions in which a company wishes to distribute its products

2. Advising on legal and scientific restraints and requirements

3. Collecting, collating and evaluating scientific data

4. Presenting registration documents to regulatory agencies and carrying out any subsequent negotiations necessary to obtain or maintain marketing authorisation for the products concerned

5. Giving strategic and technical advice at the highest level in their companies, making an important contribution both commercially and scientifically to the success of a development programme and the company as a whole

6. Helping the company avoid problems caused by badly kept records, inappropriate scientific thinking or poor presentation of data.

Additionally, the regulatory affairs department will often take part in the development of product marketing concepts and is commonly required to approve packaging and advertising before it is used commercially.4

Approval phase:

• Check progress of evaluation and anticipate questions

• Clarify raised questions, plan response and strategies with other

departments

• Plan and manage agency meetings/hearings

• Negotiate approval and Product Information with agencies

Post approval phase:

1. Compliance

Submission of variations/amendments

2. Renewals

3. Pharmacovigilance

4. Product information review

5. New indications / new formulations

Regulatory input to development plans!

6. Regulatory Intelligence

What does the future hold?

WHAT ARE THE RISKS OF REGULATORY NON-COMPLIANCE IN PHARMA?

Regulatory non-compliance is among the most significant threats to the pharmaceutical industry and can have a profound negative impact on a pharmaceutical company’s finances, reputation, and customers. Still, major pharmaceutical firms are challenged to innovate while balancing that business goal with risk mitigation. Therefore, most of the world’s leading drug companies also face similar types of risks around regulatory compliance in the pharma industry.

Rather than being satisfied with siloed views of regulatory affairs in which individual teams are responsible for ensuring regulatory compliance pharmaceutical organizations should instead strive for an enterprise-wide view of what’s happening with regulatory issues. Drug developers can also look to tech-enabled solutions to improve regulatory compliance. For instance, the use of big data in the pharma industry is increasing across the organization, from research and development to marketing. Regulatory affairs should explore whether this type of disruptive innovation in pharma can decrease the risk of pharma compliance issues.6

CHALLENGE TO REGULATORY AFFAIRS PROFESSION:

Regulatory affairs include complete dynamics:

• Multi –dimensional

• Knowledge in science and technology

• Prolific communication skill

• Deal with people with diverse background, skills, culture, and personalities

• Deal with conflicting loyalties, motivations, social and ethical, responsibilities

Case in point: submission of a dossier

During submission of a dossier a regulatory affair would be:

• Guided by various regulatory guidance

• Receiving input from various department within the firm about process capabilities and product attribute specification

• Receiving advice from peers about easy way to get approvals

• Receiving motivation from the management through incentives for achieving speedy approvals.3

ORGANIZATIONAL STRUCTURE OF REGULATORY AFFAIRS:

Not unified across the companies and is changing

• Global regulatory affairs

• Regional regulatory affairs

• Local regulatory affairs

• Manufacturing site regulatory affairs

• Drug Agency regulatory affairs

The structure will depend on size, type and culture of the company

and the personalities involved.3

REGULATORY BODIES IN THE WORLD:

Country Regulatory authorities

USA Food and Drug Administration (FDA)

UK Medicines and Healthcare Products Regulatory Agency (MHRA)

Australia Therapeutic Goods Administration (TGA)

India Central Drug Standard Control Organization (CDSCO)

Canada Health Canada

Europe European Medicines Agency (EMEA)

Denmark Danish Medicines Agency

Costa Rica Ministry of Health

New Zealand Medsafe - Medicines and Medical Devices Safety Authority

Sweden Medical Products Agency (MPA)

Netherlands Medicines Evaluation Board

Ireland Irish Medicines Board

Italy Italian Pharmaceutical Agency

Nigeria

National Agency for Food and Drug Administration and Control (NAFDAC)

Ukraine Ministry of Health

Singapore

Centre for Pharmaceutical Administration Health Sciences Authority

Hong Kong

Department of Health: Pharmaceutical Services

Paraguay Ministry of Health

Sweden Medical Products Agency (MPA)

Thailand Ministry of Public Health

China State Food and Drug Administration

Germany Federal Institute for Drugs and Medical Devices

Malaysia National Pharmaceutical Control Bureau,Ministry of Health

Pakistan Drugs Control Organization, Ministry of Health

South Africa Medicines Control Council

Sri Lanka SPC, Ministry of Health

Switzerland Swissmedic, Swiss Agency for Therapeutic Products

Uganda Uganda National Council for Science and Technology (UNCST)

Brazil Agencia Nacional de Vigiloncia Sanitaria (ANVISA )

Japan Ministry of Health, Labour & Welfare(MHLW)

INTERNATIONAL ORGANIZATIONS:

World Health Organization (WHO)

Pan American Health Organization (PAHO)

World Trade Organization (WTO)

International Conference on Harmonization (ICH)

World Intellectual Property Organization (WIPO)

REGULATORY AFFAIRS IN CLINICAL TRIALS:

The RA professional is the primary link between the company and worldwide regulatory agencies such as US Food and Drug Administration (USFDA & Center for Devices and Radiological Health), Medicines and Healthcare Products Regulatory Agency, United Kingdom, (UKMCA), Therapeutic Goods Administration, India Central Drug Standard Control Organization (CDSCO), Australia European Medicines Agency, Organization of Economic Collaboration and Development (OECD) and Health Canada. It also communicates and interprets the seemingly endless mace of laws, regulations and guidelines to the other departments of the company. The RA personnel develops strategies to overcome delays and presents finding of clinical trials to the regulatory bodies so as to get quick clearance, thus reducing the time for approval of new molecules. At its core, the RA professional facilitates the collection, analysis and communication about the risks and benefits of health products to the regulatory agencies, medical and health systems and the public. Operationally RA is responsible for assuring that government obligation, market driven demands and evolving scientific conventions are understood and addressed by various stakeholders.8

REGULATORY AFFAIRS IN R&D

The regulatory affairs personnel work hand in hand with marketing and R&D to develop, innovative products that take advantage of new technological and regulatory developments to accelerate time to market. With new products expected to add significant revenues to the company’s bottom lines, small decreases in time to market equate to large material gains in revenue and profit. Employing adaptive clinical trial strategies, obtaining quick approval from regulatory authorities and avoiding pitfalls in processes can accelerate development of new products and help to reduce costly errors and time lags.8

GLOBAL MARKET IS DIVIDED INTO:

1. Regulated Market:

US, EU (UK, Germany, France, Ireland, Sweden etc.), Japan, Canada, Australia, New Zealand, South Africa

2. Semi regulated Market (ROW Countries):

(a) Asia (Sri Lanka, India, Bangladesh,; ASEAN: 10 Countries group - Philippines, Vietnam, Singapore, Malaysia, Thailand, Indonesia, Laos, Cambodia, Brunei Darussalam, Myanmar

(b) African countries (Algeria, Zambia, Ethiopia, Ghana, Kenya, Malawi, Mozambique, Namibia, Nigeria, Sierra Leone, Tanzania, Zimbabwe etc.)

(c) Middle East countries (Gulf Co-operation Council countries i.e. Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, UAE)

(d) Latin America (Mexico, Brazil, Panama, Peru, Guatemala, Argentina, Chile, Dominican Republic)

(e) CIS (common wealth of independent states): Russia, Ukraine, OFSUs (Armenia, Azerbaijan, Belarus, Georgia, Kazakhstan, Kirghizstan, Moldova, Tajikistan, Turkmenistan, Uzbekistan etc.)

CONCLUSION:

In conclusion, regulatory affairs play a pivotal role in the pharmaceutical industry, serving as a crucial bridge between scientific innovation and public health. The complex and ever-evolving landscape of regulations and guidelines requires pharmaceutical companies to navigate a myriad of requirements to ensure compliance and bring safe and effective products to market.

Throughout this article, we have explored the roles of regulatory professional and their involvement in ensuring safety, efficacy, and quality of drugs. Initially we discussed about their roles in each stage of the drug development process. The historical overview, stating “Elixir Sulfanilamide incident” and various Acts and rules in India during 20th century was reviewed. We now have a great understanding about organizational structure and various regulatory bodies across the world. As we know, regulatory professionals work hand in hand with clinical trail and R&D to develop innovative product, they can also face regulatory non-compliance. It can overcome through various exploration and strategies by the professionals. Thus, we finally discussed about the global market and its division into two groups such regulated market and semi-regulated market.

REFERENCES:

1. Dinesh Kawade, Manali Sahastrabuddhe, Mahima Dubey, Mukul Gadodiya, Nayan Gore and Manish Kinkar; An overview of regulatory affairs in pharmaceutical industries, Volume 8, Issue 6. Available online at: https://www.jetir.org/papers/JETIR2106052.pdf

2. Mr. Pritam R. Salve, Mr. Vaibhav A. Jadhav, B. Pharm., Pratibhatai Pawar College of Pharmacy; Review on drug regulatory affairs and new drug approval process in India. Available online at: https://ijrpr.com/uploads/V3ISSUE7/IJRPR5798.pdf

3. Keshari Roshan; Role of regulatory affairs in pharmaceutical company: An overview. Availble online at: https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/recent_issues_pdf/2018/January/January_2018_1515152068__76.pdf

4. What is regulatory affairs in the pharma industry, and how can technology help? Availble online at: https://within3.com/blog/what-is-regulatory-affairs-in-pharma-industry

5. What is regulatory affairs? Availble online at: https://www.topra.org/TOPRA/TOPRA_Member/What_is_regulatory_affairs.aspx

6. Orin Chisholm and Helen Critchley, Faculty of Medicine and Health, Sydney Pharmacy School, The University of Sydney, Sydney, NSW, Australia; Future directions in regulatory affairs.

7. Dhananjay D. Chaudhari, Mohit R. Koli; Drug regulatory affairs: short review.

8. Subash Philip & Ansa Philip; The Scope of Regulatory Affairs in the Pharmaceutical Industry. Availble online at: https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=358b612493ff7b225668face3e8b242dd4265645

9. CDSCO; https://cdsco.gov.in/opencms/opencms/en/Acts-and-rules/

10. US FDA; https://www.fda.gov/

11. Janjal, V., Dhamodkar, S., Jadhao, Y., Manmode, S., Pawat, A. and Khandelwal, H., 2021. Review article on Recent drug regulatory affairs and CTD module progress review for submission of pharmaceutical product.

12. Kumar, S., Panwar, R. and Singh, U., 2013. “Regulatory affairs in the pharmacy curriculum”

13. Chandra, A. and Kumar, B., 2016. A comparitive study of the drug approval process in USA, INDIA, JAPAN AND EUROPE. World journal of pharmaceutical Research.

14. Rahalkar H (2012) Historical Overview of Pharmaceutical Industry and Drug Regulatory Affairs. Pharmaceutical Regulatory Affairs S11:002. doi:10.4172/2167-7689.S11-002

15. Hasumati Rahalkar, Historical Overview of Pharmaceutical Industry and Drug Regulatory Affairs, Pharmaceutical Regulatory Affairs, Pharmaceutical Regulatory Affairs: Open Access; 2012.

@medicine @knowledge

[sufferfly1]

Glycols Market : A View of the Industry's Advancements and Opportunities

The global glycols market size is anticipated to reach USD 49.36 billion by 2026 growing at a CAGR of 5.1% from 2018 to 2026 according to a new report published by Polaris Market Research.  The report ‘Glycols Market Share, Size, Trends, & Industry Analysis Report, By Product (Propylene Glycol, Ethylene Glycol (Mono-ethylene Glycol, Di-ethylene Glycol, Tri-ethylene Glycol), By Applications (Textiles, Automotive, HVAC, Medical, Airline, Others), By Regions: Segment Forecast, 2018 – 2026’provides insights on the current market scenario and the future prospects. Increasing demand for ethylene and propylene glycol is owing to its increasing demand from a many primary end-use industries.

 Large volumes of ethylene glycols are consumed for manufacturing of automotive coolant or antifreeze. Ethylene glycols are non-corrosive, stable chemicals with high flash points. Propylene glycols are relatively nontoxic liquids that are practically odorless and colorless. Some of its primary applications include heat transfer fluids, paints & coatings, antifreeze coolants, functional fluids and plasticizers.

 The hygroscopicity of these products makes it an important conditioning agent in in vinyl floor tiles, cork, adhesives, cellulose sponges, synthetic rubbers, printing inks and paper products. Ethylene glycol is also used in formulations development of the alkyd-type resins that has linear chain structures and even in unsaturated polyester resins. It is also used in the dehydration of natural gas. Apart from these the product has several applications in polyester, textile, HVAC, medical, airline and food & beverage industry.

 Have Questions? Request a sample this report by clicking the link below: https://www.polarismarketresearch.com/industry-analysis/glycols-market/request-for-sample

 MEG is the largest volume product produced of all the ethylene glycols. Polyester grade EG are among the leading application-based product production. This product grade is used in manufacturing of PET resins, fibers and several other substances such as tire cords, textiles, soft drinks, video tapes and water containers.

 The high purity and industrial grade EG are utilized in formulation of various products that require hygroscopic, solvent, or high boiling point physiognomies. Some of these end-use products include printing inks, paints, cleaners, heat transfer fluids, hydraulic fluids, and electronics. The antifreeze grade EG is one of the major primary components in manufacturing of engine coolants especially for automotive.

Diethylene glycol (DEG) has excellent solvent properties and has higher boiling point, specific gravity and viscosity. Some of the primary applications of DEG include adhesives, heat transfer fluids, cement processing and cleansers. Moreover, it is also used as a chemical intermediate in the production of polyurethanes and unsaturated polyester resins.

 Application segments of these products has increased significantly over the years as a synchrony or as a result of development and production of high quality of customer specific grades of these products and hence demand for these products has been increasing and is also anticipated to increase further in the near future.

However, owing to constant price volatility in petrochemicals production over the past few years, prices of ethylene and propylene glycol has also been fluctuating over the past two years across all the regional markets. This was owing to the different demand supply trends of the product in all the regional markets and as an attempt to meet that, product prices have been significantly affected.

In 2017, Asian Pacific glycols industry faced a few challenges in terms of longer supply terms and slower market growth in the downstream polyester terephthalate (PET), polyester fiber and yarn sectors. The listing of monoethylene futured as a product in the China’s Dalian Commodity Exchange (DCE) and added certain uncertainty to MEG price movements. In 2016 as well, the Asia Pacific market experienced volatility and was a challenging market space.

 However, the average global prices of MEG saw gains in the first quarter of 2017 though it stabilized by the end of the year. It was mainly due to the increase in demand for polyester fibers from other regional markets and an overall reduction in production output from the major global suppliers of MEG.

 The worldwide glycols market is a competitive marketspace with moderate degree of integration across the value chain by several market players. Some of the lading market participants include ExxonMobil Corporation, Saudi Basic Industries Corporation (SABIC), Dow Dupont, Royal Dutch Shell plc, LyondellBasell Industries, Total S.A., and China Petroleum & Chemical Corporation.

 Polaris Market Research has segmented the global glycols market on the basis of product, application and region:

Glycols Product Outlook (Revenue, USD Billion, 2015 – 2026)

Propylene glycol

Ethylene glycol

Mono-ethylene glycol

Di-ethylene glycol

Glycols Application Outlook (Revenue, USD Billion, 2015 – 2026)

Polyethylene

Textiles

Automotive

HVAC

Medical

Airline

Polyester Fiber & Resins

Food & Beverage

Others

Glycols Regional Outlook (Revenue, USD Billion, 2015 – 2026)    

North America

S.

Canada

Europe

Germany

UK

France

Italy

Spain

Belgium

Russia

Netherlands

Rest of Europe

Asia-Pacific

China

India

Japan

Korea

Singapore

Malaysia

Indonesia

Thailand

Philippines

Rest of Asia-Pacific

Latin America

Brazil

Mexico

Argentina

Rest of LATAM

Middle East & Africa

UAE

Saudi Arabia

South Africa

Rest of MEA

Purchase the Report for Key Insights:@ https://www.polarismarketresearch.com/industry-analysis/glycols-market

About Us:

Polaris Market Research is a worldwide market research and consulting organization. We give unmatched nature of offering to our customers present all around the globe across industry verticals. Polaris Market Research has expertise in giving deep-dive market insight along with market intelligence to our customers spread crosswise over various undertakings. We at Polaris are obliged to serve our different client base present over the enterprises of medicinal services, healthcare, innovation, next-gen technologies, semi-conductors, chemicals, automotive, and aerospace & defense, among different ventures, present globally.

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[endrusmithreal]

Staying Competitive: Managing Ethylene Oxide Production Costs in a Global Market

The latest report titled Ethylene Oxide Production Cost by Procurement Resource, a global procurement research and consulting firm, provides an in-depth cost analysis of the production process of Ethylene Oxide.

Procurement Resource study is based on the latest prices and other economic data available. It also offers additional analysis of the report with detailed breakdown of all cost components (capital investment details, production cost details, economics for another plant location, dynamic cost model). In addition, the report incorporates the production process with detailed process and material flow, capital investment, operating costs along with financial expenses and depreciation charges.

Request For Free Sample: https://procurementresource.com/production-cost-report-store/ethylene-oxide/request-sample

Procurement Resource’s detailed report describes the stepwise consumption of material and utilities along with a detailed process flow diagram. Furthermore, the study assesses the latest developments within the industry that might influence Ethylene Oxide production cost, looking into capacity expansions, plant turnarounds, mergers, acquisitions, and investments.

Procurement Resource Assessment of Ethylene Oxide Production Process:

1. Ethylene Oxide Production Cost From Catalytic Reaction Between Ethylene and Oxygen: This report gives a summary of the production process and expense assessment for ethylene glycol industrial production in a ethylene glycol manufacturing plant. This method involves the utilization of silver metal as a catalyst to react ethylene and oxygen in a reactor. This reaction produces ethylene oxide, water, carbon dioxide, as well as heat. Then, these produced gases are cooled and scrubbed with water and potassium carbonate solution. This process dissolves ethylene oxide, which is then extracted from the solution by distillation.

Request For Free Sample: https://procurementresource.com/cost-analysis/ethylene-oxide-production-using-catalytic-reaction-between-ethylene-and-oxygen/requestsample

2. Ethylene Oxide Production Cost From Ethylene: This report provides an overview of the production process of and expense evaluation of ethylene glycol industrial production across ethylene glycol manufacturing plant. In this method, ethylene and oxygen are reacted with each other in a reactor at temperatures ranging from 200 to 300 degrees Celsius. Further, the obtained product undergoes cooling and scrubbing by using potassium carbonate as well as water. Lastly, ethylene oxide is separated from the solution via a desorption and distillation process.

Request For Free Sample: https://procurementresource.com/cost-analysis/ethylene-oxide-production-from-ethylene/requestsample

Product Definition:

Ethylene glycol is a chemical compound represented by the formula HOCH2CH2OCH2OH. This compound is a colorless and odorless thick liquid that has low toxicity. Ethylene glycol has various applications, including automobile and textile industries. Additionally, it has three types, namely Monoethylene Glycol (MEG), Diethylene Glycol (DEG), and Triethylene Glycol (TEG). MEG has numerous applications, such as being a chemical intermediate in the production of other chemicals like polyurethanes and phthalate plasticizers. It can also be used as a coolant and heat-transfer agent, antifreeze, precursor to polymers, among others. DEG, on the other hand, is an organic compound used mainly as a precursor to polymers and as a solvent. However, DEG is toxic and can cause damage to the kidneys, liver, and central nervous system. It can also irritate the skin. Lastly, TEG is a colorless and thick liquid that is soluble in water and has a sweet taste.

Market Drivers:

The ethylene glycol market is currently experiencing a surge in demand, primarily driven by the textile and automotive industries. This increased demand can be attributed to advancements in production technology, which have made bio-based ethylene glycol a more popular and viable option. As a result, the market is expected to witness significant growth during the forecast period. The textile industry is expected to be a major contributor to this growth as it continues to expand rapidly. Additionally, the PET resin industry is also expected to see considerable growth, which will result in greater consumption of ethylene glycol. The packaging industry has also experienced a significant uptick in growth due to the changes in consumer lifestyles. As more people opt for food containers and bottles made from PET, there will be an increased demand for MEG, further boosting the ethylene glycol market.

Looking for an exhaustive and personalised report that could significantly substantiate your business?

Although Procurement Resource leaves no page unfurled in terms of the rigorous research for the commodities that make the heftiest base of your business, we incline more towards tailoring the reports per your specificities. All you need is one-to-one consulting with our seasoned consultants to comprehend the prime parameters you are looking to pin your research on.

Some of the common requests we receive from our clients include:

Adapting the report to the country/region where you intend to establish your plant.

Adjusting the manufacturing capacity of the plant according to your needs

Customizing machinery suppliers and costs to meet your requirements.

Providing additional information to the existing scope based on your needs.

About Us:

Procurement Resource ensures that our clients remain at the vanguard of their industries by providing actionable procurement intelligence with the help of our expert analysts, researchers, and domain experts. Our team of highly seasoned analysts undertakes extensive research to provide our customers with the latest and up-to-date market reports, cost models, price analysis, benchmarking, and category insights, which aid in simplifying the procurement process for our clientele.

Procurement Resource work with a diverse range of procurement teams across industries to get real-time data and insights that can be effectively implemented by our customers. As a team of experts, we also track the prices and production costs of an extensive range of goods and commodities, thus, providing you with updated and reliable data.

We, at Procurement Resource, with the help of the latest and cutting-edge techniques in the industry, help our clients understand the supply chain, procurement, and industry climate so that they can form strategies that ensure their optimum growth.

Contact Us:

Company Name: Procurement Resource Contact Person: Chris Byrd Email: sales@procurementresource.com Toll-Free Number: USA & Canada – Phone no: +1 307 363 1045 | UK – Phone no: +44 7537 132103 | Asia-Pacific (APAC) – Phone no: +91 1203185500 Address: 30 North Gould Street, Sheridan, WY 82801, USA

[chemicalresearch12]

Mono Ethylene Glycol Market on the Rise: Projected 3.2% CAGR Growth 2023-2030

The global Mono Ethylene Glycol (MEG) market has experienced significant expansion during the historic period from 2015 to 2022 and is projected to grow at a Compound Annual Growth Rate (CAGR) of 3.2% during the forecast period until 2030. This growth is primarily attributed to the increasing demand from various end-use industries, including Polyester Fibre and Yarn, PET Resin, and Polyester Film.

Mono Ethylene Glycol (MEG) is a slightly viscous, colorless, odorless organic compound with a sweet taste. It is also known as 1,2-ethanediol and is soluble in most organic compounds, alcohols, and water. MEG is mainly produced from Ethylene through the hydrolysis of Ethylene Oxide, along with the production of two co-products, Diethylene Glycol (DEG) and Triethylene Glycol (TEG). The feedstocks used for MEG production include natural gas, coal, naphtha, and bioethanol. MEG has various niche applications in resins, deicing fluids, heat transfer fluids, automobile antifreeze and coolants, water-based adhesives, latex paints, asphalt emulsions, electrolytic capacitors, textile fibers, pulp, and leather.

Click Here To Read Full Report: https://www.chemanalyst.com/industry-report/mono-ethylene-glycol-meg-market-646

About Us: 

ChemAnalyst is an online platform offering a comprehensive range of market analysis and pricing services, as well as up-to-date news and deals from the chemical and petrochemical industry, globally.

Being awarded ‘The Product Innovator of the Year, 2023’, ChemAnalyst is an indispensable tool for navigating the risks of today's ever-changing chemicals market.

The platform helps companies strategize and formulate their chemical procurement by tracking real time prices of more than 400 chemicals in more than 25 countries.

ChemAnalyst also provides market analysis for more than 1000 chemical commodities covering multifaceted parameters including Production, Demand, Supply, Plant Operating Rate, Imports, Exports, and much more. The users will not only be able to analyse historical data but will also get to inspect detailed forecasts for upto 10 years. With access to local field teams, the company provides high-quality, reliable market analysis data for more than 40 countries.

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[petrochemical07]

Exploring Key Industrial Chemicals: MEG, DEG, and More

In the world of industrial chemicals, a few substances stand out due to their versatility and importance. Monoethylene glycol (MEG) and diethylene glycol (DEG) are two key players in this space, widely used in various applications, from antifreeze to plastics. Alongside them, bentonite powder, caustic soda, sodium bicarbonate, soda ash, and barite powder are crucial materials in different industries. Understanding their uses, suppliers, manufacturers, and pricing can help businesses make informed decisions.

What is Monoethylene Glycol (MEG)?

Monoethylene glycol (MEG) is a colorless, odorless liquid that is hygroscopic (absorbs moisture from the air). It plays a vital role in several industries, including:

Textiles: Used in fiber production.

Automotive: Acts as an antifreeze and coolant.

Packaging: Serves as a precursor to polyethylene terephthalate (PET) used in plastic bottles.

Key Characteristics of MEG

Chemical Formula: C2H6O2

Boiling Point: 197.3 °C (387.1 °F)

Viscosity: Low, making it easy to handle in manufacturing processes.

MEG Suppliers and Manufacturers

When sourcing MEG, it's essential to work with reliable suppliers and manufacturers. They ensure consistent quality and supply stability. Notable MEG suppliers include large chemical companies like BASF, LyondellBasell, and SABIC. These companies maintain high production standards and provide a range of grades to meet specific industry needs.

Pricing Trends for MEG

The price of monoethylene glycol can fluctuate based on factors like:

Feedstock costs: Ethylene and natural gas prices impact MEG production costs.

Demand-supply dynamics: Seasonal demands in the automotive and textile sectors can affect pricing.

As of recent reports, the average price of MEG stands around $1,000 to $1,200 per metric ton, but it varies by region and market conditions.

Understanding Diethylene Glycol (DEG)

Diethylene glycol (DEG) is another essential glycol, similar to MEG, but with a slightly different structure and applications. DEG is mainly used in:

Solvent applications: It's a great solvent for resins and oils.

Manufacturing plastics: Acts as a plasticizer.

Antifreeze formulations: Helps lower the freezing point of fluids.

Characteristics of DEG

Chemical Formula: C4H10O3

Boiling Point: 245 °C (473 °F)

Viscosity: Higher than MEG, making it useful in specific formulations.

DEG Suppliers and Manufacturers

Top DEG suppliers include reputable companies such as OxyChem, Shell, and Eastman Chemical Company. These manufacturers offer various grades of DEG tailored for specific applications.

Current Pricing for DEG

The price of diethylene glycol can be influenced by similar factors as MEG, including global oil prices and market demand. Currently, DEG prices hover around $1,200 to $1,500 per metric ton.

Exploring Bentonite Powder

Bentonite powder is a clay material derived from volcanic ash, known for its unique properties. It's commonly used in:

Drilling fluids: Helps stabilize boreholes in the oil and gas industry.

Cat litter: Absorbs moisture and odor.

Construction: Used as a binding agent.

Bentonite Suppliers and Manufacturers

Key players in the bentonite market include American Colloid Company, Wyo-Ben, and Bentonite Performance Minerals. They provide high-quality bentonite tailored for various applications.

Pricing Trends for Bentonite

The price of bentonite varies based on quality and application but typically ranges from $100 to $300 per ton.

Caustic Soda (Sodium Hydroxide)

Caustic soda, or sodium hydroxide, is a highly versatile chemical used across multiple industries, including:

Pulp and paper: For pulping wood.

Textiles: In the dyeing process.

Food processing: As a pH regulator.

Suppliers and Manufacturers

Major caustic soda suppliers include Olin Corporation, Dow Chemical, and Koch Industries. They ensure quality and consistent supply.

Pricing for Caustic Soda

The price of caustic soda can vary widely, currently falling between $300 and $500 per ton, depending on purity and supplier.

Sodium Bicarbonate

Sodium bicarbonate, or baking soda, is a common compound with applications in:

Food: As a leavening agent.

Pharmaceuticals: In antacids.

Cleaning products: For its mild abrasive properties.

Sodium Bicarbonate Suppliers

Top suppliers include Arm & Hammer, Solvay, and Tata Chemicals. These companies provide a range of sodium bicarbonate products for different uses.

Pricing Trends

The price of sodium bicarbonate typically ranges from $200 to $400 per ton based on market demand and purity levels.

Soda Ash (Sodium Carbonate)

Soda ash is essential in glass production, detergent manufacturing, and chemical processing. It's a key ingredient that:

Acts as a flux in glass making: Lowers the melting point of silica.

Used in water treatment: Helps control acidity.

Suppliers and Manufacturers

Major players in the soda ash market include Nirma Limited, OCI Chemical Corporation, and Ciner Resources. They offer both natural and synthetic soda ash.

Pricing for Soda Ash

The price of soda ash can fluctuate but generally sits between $150 and $250 per ton.

Barite Powder

Barite powder is a mineral used primarily in the oil and gas industry for drilling fluids. Its high density makes it valuable for:

Well drilling: Stabilizes boreholes and reduces fluid loss.

Paints and coatings: Provides a white pigment.

Suppliers and Manufacturers

Notable barite suppliers Petrochemical include Schlumberger, Halliburton, and Excalibar Minerals LLC. They ensure high-quality products for the drilling industry.

Current Pricing for Barite

The price of barite typically ranges from $100 to $200 per ton, depending on quality and processing.

Conclusion

Understanding the complexities of these industrial chemicals—MEG, DEG, bentonite powder, caustic soda, sodium bicarbonate, soda ash, and barite powder—helps businesses make better purchasing decisions. Each chemical serves critical roles across various industries, and knowing the key suppliers and pricing trends is essential for effective procurement strategies. By focusing on reliable suppliers and staying informed about market dynamics, businesses can optimize their operations and maintain a competitive edge.

[iasguidance]

CDSCO Report Uncovers Alarming Levels of Contaminants in Indian Cough Syrups

Context: According to a report released by the Central Drugs Standard Control Organisation (CDSCO), the nation’s top drug regulator, at least five batches of cough and allergic rhinitis syrups from two Indian manufacturers have been found to contain higher than permissible levels of contaminants – diethylene glycol and ethylene glycol. About Ethylene glycol and Di Ethylene Glycol (DEG) Ethylene…

[chemanalystdata]

Diethylene Glycol Prices Trend | Pricing | Database | Index | News | Chart

 North America:

During the first quarter of 2024, the North American Diethylene Glycol (DEG) market experienced significant challenges that drove prices upwards. A bullish market emerged due to a limited supply caused by the closure of several production plants amid severe cold weather. The high demand in the antifreeze sector, driven by freezing temperatures, further fueled price increases. Additionally, fluctuations in raw material costs and strong demand for automobile antifreeze impacted the market.

In the United States, similar factors led to significant price changes. Prices remained stable during the first two months, supported by existing inventory levels meeting downstream demand. However, the final month of the quarter saw a surge in prices due to constrained supply exacerbated by disruptions in freight, particularly from the Red Sea incident. Price adjustments by key players, including Indorama Venture, also influenced market trends.

In summary, the DEG market in North America, particularly in the United States, saw price increases during the first quarter of 2024. Key drivers included heightened demand from downstream industries, fluctuating raw material costs, and increased freight charges. In the US, DEG prices rose by over 14% compared to the same quarter the previous year and by more than 13% compared to the preceding quarter of 2023.

Get Real Time Prices for Diethylene Glycol (DEG): https://www.chemanalyst.com/Pricing-data/diethylene-glycol-66

APAC:

The Diethylene Glycol (DEG) market in the APAC region witnessed steady demand during the first quarter of 2024. The market showed signs of recovery after a decline in the previous quarter, as downstream industries began to increase their demand. Although there were some concerns regarding high stock inventories, the market managed to maintain a moderate level of demand. Volatile crude oil prices impacted the prices of DEG and its derivatives. South Korea, one of the key players in the market, experienced stable supply levels, ensuring uninterrupted production activities. However, logistics freight charges slightly affected the product's price, resulting in a minor decrease in the latter half of the quarter. Despite this, sellers maintained their profit margins due to the limited availability of materials in the region. The top three factors influencing the market during the quarter were the recovery in demand from downstream industries, fluctuating crude oil prices, and limited material availability. Fortunately, no plant shutdowns were reported during this period. DEG prices in South Korea showed an 8% increase compared to the same quarter last year and a slight increase of 12% compared to the previous quarter of 2023.

Europe:

In the first quarter of 2024, the European Diethylene Glycol (DEG) market faced several factors influencing price dynamics. Plant closures led to limited supply, tightening availability, and pushing prices upwards. Multiple shutdowns across the region exacerbated these constraints. Additionally, ongoing geopolitical tensions in the Red Sea area disrupted global trade routes, driving up freight costs and further impacting DEG prices. In Germany, a key player in the European market, DEG trends were bullish. Increased demand from sectors like polyester and polyurethane collided with transportation disruptions caused by strikes and adverse weather conditions. These disruptions, coupled with plant closures, contributed to rising freight charges and logistical complexities, further impacting DEG prices in the country. As a result, the first quarter's price of DEG CFR Hamburg in Germany stood at USD 1150/MT, marking a significant increase compared to the same period the previous year and signaling positive price momentum. In summary, during the first quarter of 2024, the DEG market in Europe faced supply limitations, transportation disruptions (including strikes and adverse weather conditions), and fluctuations in feedstock prices. Germany specifically felt the effects of these factors, influencing the pricing dynamics of DEG in the region.

Get Real Time Prices for Diethylene Glycol (DEG): https://www.chemanalyst.com/Pricing-data/diethylene-glycol-66

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[shahananasrin-blog]

[ad_1] Defendants and lawyers attend a court hearing in the case of child deaths linked to contaminated cough syrups, in Tashkent, Uzbekistan August 16, 2023. — Reuters/FileThe US FDA is addressing lax testing practices by healthcare product manufacturers following a review of regulatory alerts.At least 28 companies have been reprimanded this year for failing to prove sufficient testing of ingredients used in over-the-counter drugs and consumer products for ethylene glycol (EG) and diethylene glycol (DEG), according to a Reuters analysis of agency import alerts and warning letters to manufacturers.The manufacturers include US-based companies and exporters from India, South Korea, Switzerland, Canada and Egypt.The FDA has flagged more manufacturers for failing to test raw materials susceptible to EG and DEG contamination in 2023 than in the previous five years combined, the Reuters analysis found.The FDA told Reuters it has no indication products contaminated with DEG and EG have entered the US supply chain, and that the number of warning letters issued in a given period "is not a comprehensive marker of our oversight."Peter Lindsay, a lawyer at Paul Hastings in Washington, DC who specialises in FDA regulation and compliance, said to better spot contamination the agency was now requiring manufacturers to check individual containers of ingredients rather than just sampling raw materials."They're upping the bar a little bit and trying to get industry to understand and recognize some of the risks in these areas," he said.Cough syrups made in India and Indonesia have been linked to the deaths of more than 300 children globally. The medicines were found to contain high levels of DEG and EG, leading to acute kidney injury and death.The poisonings have sparked criminal probes, lawsuits and a surge in regulatory scrutiny worldwide. Reuters reported earlier this month that some Indian drugmakers involved could not prove they had purchased pharmaceutical-grade ingredients or tested their medicines for the toxins.In the United States, more than 100 people, most of them children, died in the 1930s from DEG poisoning, prompting laws that greatly enhanced the FDA's regulatory power over drugs.Yet the agency did not establish explicit rules to test high-risk ingredients like propylene glycol (PG) and sorbitol solution for EG and DEG until May 2023.Previous guidance from 2007 recommended certain tests be performed on glycerin, another common ingredient in over-the-counter drugs and consumer goods, to prevent the distribution of DEG-contaminated products. It now requires the same scrutiny of PG and other high-risk components for DEG and EG.Import alertsThe FDA warning letters give manufacturers an opportunity to fix quality control problems or face penalties.The letters sent to the 28 US and foreign manufacturers threaten to block either exports or imports of their products and new drug applications from those firms if they do not improve testing practices.Half of them also received import alerts, which prohibit at-risk products from entering the country by allowing customs officials to detain them without examination.Eleven of the manufacturers cited by the FDA this year marketed some of their at-risk products to children, including diarrhoea and pink eye medicines, toothpaste and sunscreen, according to the letters.Florida-based Lex, a contract manufacturer of cough and cold medicines that can be used by children, was called out by the FDA on Aug. 17 for lax testing and repeated quality-control violations going back to 2004.Lex co-owner Charlene Paz said the company has addressed the shortcomings identified by the FDA and is conducting all required tests for impurities whenever they get ingredients susceptible to EG and DEG contamination.Fourteen foreign manufacturers that sold products susceptible to DEG and EG poisoning were placed on import alert lists for failure to prove sufficient quality control. They include South Korea's LCC, which makes Oriox and other mouthwashes, and India-based toothpaste manufacturers Suhan Aerosol and Orchid Lifesciences.An LCC spokesperson said the company is in the process of responding to the FDA. Suhan and Orchid said EG and DEG were not found in their products.Four of the 14 companies were put on an import alert list for not responding to requests for records. They are Daxal Therapeutics and Skyline Herbals from India, and South Korea’s KM Pharmaceutical and Sangleaf Pharma. They could not be reached for comment.In addition, 13 US makers of consumer products like earwax removers, nasal spray, hand soap and shampoo, including Lex, were threatened with possible seizures and injunctions by the FDA.The regulator said they had failed to conduct required contamination checks, in several cases relying on suppliers’ certificates of analysis for the purity of their ingredients, among other shortcomings.Greg Landry, a pharmacology and toxicology expert at Massachusetts College of Pharmacy & Health Sciences, noted the difficulty of policing every consumer product. But when the FDA becomes aware of a problem, he said, "their response is usually swift and mighty." [ad_2]

[namansharma0950]

디에틸렌 글리콜 가격 동향: 상세 차트, 시장 분석 및 향후 전망

디에틸렌 글리콜(DEG)은 부동액 및 개인 위생 제품부터 의약품, 심지어 식품 첨가물에 이르기까지 광범위한 응용 분야를 갖춘 다용도 산업용 화학 물질입니다. DEG에 의존하는 기업의 경우, 끊임없이 변화하는 DEG 가격 환경을 탐색하는 것은 정보에 입각한 구매 결정과 비용 최적화를 위해 매우 중요합니다. 그러나 정확한 최신 DEG 가격 정보를 얻는 것은 어려울 수 있습니다.

디에틸렌 글리콜 가격에 영향을 미치는 요인

DEG 가격을 결정하는 데에는 다음과 같은 여러 요소가 중요한 역할을 합니다.

공급원료 비용: DEG 생산의 주요 원료인 에틸렌 글리콜은 최종 가격에 큰 영향을 미칩니다. 에틸렌 글리콜 가격의 변동은 DEG 가격 변동으로 직접적으로 해석됩니다. 공급 및 수요 역학: 수요와 공급에 대한 시장 힘의 상호작용은 매우 중요합니다. DEG 공급이 수요를 초과하면 가격이 하락하는 경향이 있습니다. 반대로 제한된 공급과 높은 수요는 가격을 상승시킬 수 있습니다. 원유 가격: 석유 파생상품인 원유 가격 변동은 DEG 가격에 간접적으로 영향을 미칠 수 있습니다. 에틸렌 글리콜 생산은 탄화수소에 의존하기 때문에 원유 가격 급등은 DEG 비용 증가로 이어질 수 있습니다. 지리적 위치: 운송 비용, 수입 관세 및 현지 시장 역학으로 인해 DEG 가격에 지역적 차이가 있습니다. 조달 전문가는 국제 공급업체로부터 DEG를 조달할 때 이러한 요소를 고려해야 합니다. 경쟁력 있는 디에틸렌 글리콜 가격을 찾기 위한 전략

화학 시장 분석 보고서: 평판이 좋은 화학 시장 조사 회사의 보고서를 구독하면 DEG 가격 동향, 예측 및 영향 요인 분석에 대한 귀중한 통찰력을 얻을 수 있습니다. 온라인 가격 집계자: 여러 온라인 플랫폼이 다양한 DEG 공급업체의 가격 데이터를 집계합니다. 이러한 플랫폼은 다양한 공급업체의 가격을 빠르고 편리하게 비교할 수 있는 방법을 제공할 수 있습니다. 직접적인 공급업체 커뮤니케이션: 신뢰할 수 있는 DEG 공급업체와 강력한 관계를 구축하면 가격을 직접 협상하고 잠재적으로 특히 대량 구매의 경우 더 나은 거래를 확보할 수 있습니다. 산업 협회 보고서: 화학 산업 협회는 귀중한 DEG 가격 정보가 포함된 시장 보고서를 종종 발행합니다. 리드 생성을 위한 DEG 가격 지식 활용

DEG 가격을 이해하는 것은 단순히 가장 저렴한 옵션을 찾는 것 이상입니다. 이 지식이 어떻게 리드 생성으로 전환될 수 있는지는 다음과 같습니다.

실시간 디에틸렌 글리콜(DEG) 가격 추적: https://www.analystkorea.com/Pricing-data/diethylene-glycol-deg-1094

비용 절감 파트너 되기: DEG 시장 동향에 따라 구매 결정을 최적화함으로써 잠재 고객을 위한 귀중한 파트너로 자리매김하여 고객이 비용 절감을 달성하도록 도울 수 있습니다. 효과적인 협상: DEG 가격 책정에 대한 지식을 통해 공급업체와 보다 효과적으로 협상하고 고객을 위한 최상의 거래를 확보하여 가치 제안을 강화하고 새로운 리드를 유치할 수 있습니다. 신뢰할 수 있는 공급업체 관계 구축: DEG 가격 책정에 대한 전문성을 입증하면 공급업체와의 신뢰가 강화됩니다. 이는 장기적으로 더 나은 가격 조건을 제공하고 새로운 비즈니스 기회의 문을 열어줄 수 있습니다. DEG 가격 책정을 마스터함으로써 귀하는 경쟁 우위를 확보하고 DEG 시장에서 성공적인 리드 생성 잠재력을 발휘할 수 있습니다. 정보를 지속적으로 유지하는 것은 고객의 비용을 최적화하고 원활한 공급망을 보장하여 궁극적으로 비즈니스를 번창시키는 데 핵심입니다.

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